Publications

Use of a novel docosahexaenoic acid formulation vs control in a neonatal porcine model of short bowel syndrome leads to greater intestinal absorption and higher systemic levels of DHA

Camilia R. Martin, Barbara Stoll, Joanne Cluette-Brown, Adesola C. Akinkuotue, Oluyinka O. Olutoye, Kathleen M. Guraf, Pratibha Singhd, Munir M. Zamand, Michael C. Perillo, Mark Puderg, Steven D. Freedman, Doug Burrin Abstract Infants with short bowel syndrome (SBS) are at high risk for malabsorption, malnutrition, and failure to thrive. The objective of this study was … Continue reading Use of a novel docosahexaenoic acid formulation vs control in a neonatal porcine model of short bowel syndrome leads to greater intestinal absorption and higher systemic levels of DHA

Minimal food effect for eicosapentaenoic acid and docosahexaenoic acid bioavailability from omega-3 acid ethyl esters with an Advanced Lipid TechnologiesTM (ALT®)-based formulation

M.A. Lopez-Toledano, T. Thorsteinsson, A.A. Daak, K.C. Maki, C. Johns, A.L. Rabinowicz, and Fred Sancilio Highlights SC401, is a new formulation of omega-3 fatty acids with enhanced bioavailability. SC401 has Advanced Lipid TechnologiesTM (ALT®) that forms stable micelles. SC401 reduces the food effect on DHA and EPA bioavailability. SC401 could be a good treatment for … Continue reading Minimal food effect for eicosapentaenoic acid and docosahexaenoic acid bioavailability from omega-3 acid ethyl esters with an Advanced Lipid TechnologiesTM (ALT®)-based formulation

Bioequivalence Demonstration for Ω-3 Acid Ethyl Ester Formulations: Rationale for Modification of Current Guidance

Kevin C. Maki, Colleen Johns,  William S. Harris,  Mark Puder,  Steven D. Freedman, Thorsteinn Thorsteinsson, Ahmed Daak, Adrian L. Rabinowicz, and Frederick D. Sancilio Abstract The US Food and Drug Administration (FDA) draft guidance for establishing bioequivalence (BE) of ω-3 acid ethyl esters (containing both eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA] as ethyl esters), used … Continue reading Bioequivalence Demonstration for Ω-3 Acid Ethyl Ester Formulations: Rationale for Modification of Current Guidance

A Novel ω-3 Acid Ethyl Ester Formulation Incorporating Advanced Lipid TechnologiesTM (ALT®) Improves Docosahexaenoic Acid and Eicosapentaenoic Acid Bioavailability Compared with Lovaza®

Miguel A. Lopez-Toledano, Thorsteinn Thorsteinsson,  Ahmed Daak, Kevin C. Maki, Colleen Johns,  Adrian L. Rabinowicz, and Frederick D. Sancilio Abstract Purpose: The US Food and Drug Administration has approved several highly purified ω-3 fatty acid prescription drugs for the treatment of severe hypertriglyceridemia. These differ in the amounts and forms of docosahexaenoic acid (DHA) and/or … Continue reading A Novel ω-3 Acid Ethyl Ester Formulation Incorporating Advanced Lipid TechnologiesTM (ALT®) Improves Docosahexaenoic Acid and Eicosapentaenoic Acid Bioavailability Compared with Lovaza®

Effect of omega-3 (n−3) fatty acid supplementation in patients with sickle cell anemia: randomized, double-blind, placebo-controlled trial1,2,3

Ahmed A Daak,  Kebreab Ghebremeskel, Zahir Hassan, Bakhita Attallah,  Haj H Azan, Mustafa I Elbashir, and Michael Crawford Abstract Background: Blood cell aggregation and adherence to vascular endothelium and inflammation play a central role in vaso-occlusive crisis in sickle cell disease. The antiaggregatory, antiadhesive, antiinflammatory, and vasodilatory omega-3 (n−3) fatty acids (DHA and EPA) are significantly reduced in patients … Continue reading Effect of omega-3 (n−3) fatty acid supplementation in patients with sickle cell anemia: randomized, double-blind, placebo-controlled trial1,2,3

Prevention Of Cardiovascular Disease with Omega-3 Polyunsaturated Fatty Acids

Large scale-epidemiological studies and recent clinical studies have demonstrated that individuals at risk for coronary heart disease (CHD) benefit from consuming omega-3 long-chain polyunsaturated fatty acids (n-3FA). Download the PDF file here: Prevention Of Cardiovascular Disease with Omega-3 Polyunsaturated Fatty Acids (PDF)

A Dietary Supplement with a High Eicosapentaenoic Acid to Docosahexaenoic Acid Ratio Reduces Triglyceride Levels in Mildly Hypertriglyceridemic Subjects

A Dietary Supplement with a High Eicosapentaenoic Acid to Docosahexaenoic Acid Ratio Reduces Triglyceride Levels in Mildly Hypertriglyceridemic Subjects. Download the PDF file here: A Dietary Supplement with a High Eicosapentaenoic Acid to Docosahexaenoic Acid Ratio Reduces Triglyceride Levels in Mildly Hypertriglyceridemic Subjects

Busting the Most Common Fish Oil Myths

If you take a fish oil supplement to help lower your LDL cholesterol, you’re wasting your money. The same may hold true if you think there’s not much difference between the various types of fish oil and omega-3 supplements on store shelves except perhaps the capsule sizes (and the size of the smelly, fishy belches […]

Sancilio – Genesis Study

A dietary supplement with a high Eicosapentaenoic Acid to Docosahexaenoic Acid ratio reduces Triglycerirde Levels in Mildly Hypertriglyceridemic subjects. Download the PDF file here: Sancilio – Genesis Study

Quantitative FTIR Analysis of Paraben in Finished Dosage Pharmaceuticals

Parabens are the most widely used preservatives in the pharmaceutical industry due to their broad antimicrobial properties, relatively low toxicity, low volatility, and high stability. Parabens are esters of p-hydroxybenzoic acid, which are active against yeast, fungi, molds, and Gram-positive bacteria (1). Activity increases with increased alkyl chain length (butyl> propyl> ethyl> methyl) and parabens […]

Development and Validation of a Single HPLC Method for Analysis of Purines in Fish Oil Supplements

Gout is one of the most common forms of inflammatory arthritis, affecting over 8 million adults in the US. Individuals with gout are advised to avoid the habitual intake of purine-rich foods such as meats, seafood, purine-rich vegetables, and animal protein. An increased risk of developing or having subsequent attacks of gout is particularly associated […]

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